Pain Models Rationale, Testing and Interpretation MSNBIO 2623 - Fall 2013

Mondays, 3:30-5:00 PM, Starzl BST Room 1495

Course Director: William R. Lariviere,, BST W1356, 412-298-3684


Course Description:  This course will focus on the design and analysis of animal and human pain models and will incorporate classroom presentations about various pain models (e.g., inflammatory, neuropathic, etc.). Classroom discussions will be based on assigned readings and include the relevant history and rationale for use of different tests/models, including critical assessment of strengths/weaknesses and limitations to interpretation of outcomes. Importantly, data acquisition, analysis and presentation will be included in evaluating the interpretability of outcomes.





Reading Assignment

August 26 Fundamentals of Animal Behavior and Nociceptive Testing
Lariviere-Mogil (2009) Animal models of pain Review-Wilson & Mogil (2001) Mouse Pain Testing
September 9Inflammatory Pain ModelsAlbers-Boyce-Rustay et al (Abstract) Animal Models of Acute and Chronic Inflam. & Nocicept. Pain-Zhang et al (Abstract) Animal Models of Inflam. Pain
September 16Neuropathic Pain Models IOudega-Baron (2009) Neuropathic Pain-Hulsebosch et al (2009) Mechanisms of chronic neuropathic pain
September 23Neuropathic Pain Models IIGold-Jaggi et al (2009) Neuropathic pain models
September 30Visceral Pain ModelsGebhart-Sandner-Kiesling & Bantel - New models for visceral pain
October 7Orofacial/Head Pain ModelsGold-Hargreaves (2011) Orofacial pain
-Krzyzanowska Avendario (2011) Behav testing in orofacial pain - review
October 21Other Pain ModelsDavis-Currie et al (2013) Meta analysis of bone cancer models
-Porreca et al (2013) Rev of CPP
October 28EndpointsMolliver-Bove (2006) Mechanical sensory testing
-Sneddon (Abstract) Pain perception in fish
November 4Models of Analgesic MechanismsGebhart
November 18Human Pain Models IBelfer-Olesen et al (2012) Human exp. pain models -Arendt-Nielsen & Sumikura (2002) Role of human pain models
November 25Human Pain Models IIIbinson-Brown et al (Abtract) Physiol. based measure of painBorsook & Becerra (2012) Neurosci biobev review
December 2Translation from Models to Human Clinical PainLariviere/Gold/Gebhart/others-Whiteside et al (2013) Industry on animal models
-Mogil et al (2010) Necessity of animal models
December 9Final examinationLariviere 

* Dates specific lecture topics are presented may change.

 Evaluation Methods:  Students registered in the course will be evaluated based on their participation during lectures (25%), a paper (50%), and a final examination (25%).  Students will select a topic for a paper from a given list of topics; the paper will be 10 double spaced pages, not including references, figures or tables.  The final exam will be multiple choice and/or short essay questions.


If you have a disability for which you are or may be requesting an accommodation, you are encouraged to contact both the course director and Disability Resources and Services, 216 William Pitt Union, (412) 648-7890/(412) 383-7355 (TTY), as early as possible in the term.  DRS will verify your disability and determine reasonable accommodations for this course.

Credits: 2